Elaboration of Lutein‐Loaded Nanoliposomes Using Supercritical CO ₂

A batch process for producing lutein-loaded liposomes using supercritical CO2 is studied. The effects of the variation pressure (10 and 15 MPa), temperature (308, 313, 318 K), lutein to lipid ratio (0.5 1 wt%) on liposome average size distribution are investigated, as well encapsulation efficiency (EE) lutein. This worked in a repeatable manner allowed production nanoliposomes with mean diameters (MDs) ranging from 65 ± 33 77 40 nm, obtaining EEs 82.1 3.7% 91.9 2.9%. Temperature, pressure, seem have no impact size, distribution, EE formed liposomes. use low temperatures pressures allows obtainment less than 100 nm limits energy cost. Moreover, CO2-assisted effectively encapsulates into liposome, an antioxidant molecule used prevention retinal damage. Liposomes by this desired characteristics human target delivery. Practical applications: work optimization developing environment has applications medicine. Indeed, 80 nm. In addition, excellent (hydrophobic molecules) show that constitute coating matrices protection active ingredients. These reasons make these applicable nanomedicine (injection sensitive drugs requiring before injection). elaboration also makes it possible form properties changing temperature, or lecithin concentration. Therefore, focuses function operating conditions.